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Category Archives: helminth immunology

eosinophilia: significance?

There are very few studies on the effect of helminths on humans. As a patient trying this therapy, there are few immune markers we have on hand to check immune response. We have measures of inflammation, like CRP and SED rates, but only in the research setting can one measure IL-10, [...]

3 Review Articles on the Hygiene, or Old Friends’ Hypothesis

3 new reviews in Immunology on how helminths are part of the missing link epidemiologically, along with certain other infections, and are probably the reason for the rise in autoimmunity, allergies, certain cancers, depression, nuerological diseases, and atherosclerosis. Click on the HTML or PDF link and you can read them in full.
Rook GAW; Review [...]

More articles on Hygiene Hypothesis

Another article on worms and the hygiene hypothesis from the BBC. And a detailed, follow-up article that lists the three new Immunology articles that provoked these articles. The popularity of this in recent press is very exciting. Of course, they always say they’re looking for the molecule that the worms ilicit in [...]

Helminthic Patents

Two patents on helminthic therapy:
http://www.wipo.int/pctdb/en/wo.jsp?IA=WO2006%2F014907&WO=2006%2F014907&DISPLAY=\
STATUS
http://www.freepatentsonline.com/EP1749534.html

Who needs Humira when you can have worm shots?

Worm proteins injected intraperitoneally (shot in the abdomen) ameliorate colitis in mice.

http://www3.interscience.wiley.com/journal/121530207/abstract?CRETRY=1&SRETRY=0
“Conclusions: Treatment with proteins of S. mansoni and A. caninum ameliorated TNBS-induced colitis in mice. S. mansoni proteins increased mRNA expression of regulatory cytokines while suppressing expression of proinflammatory cytokines. Therefore, we suggest a therapeutic potential for helminth proteins in the treatment of IBD.”
This [...]