I was thinking about worm dose and efficacy. (Brace yourself; this is long and convoluted.) If one were to be dosed once with 10 larvae, then accounting for attrition, there would be perhaps 7 left in the gut. (And this number may be a high estimate.) Assuming a 50% gender split, there would be 3 [...]
Tuesday, December 30, 2008
http://www.cumc.columbia.edu/dept/ps/2007/para/old/transcript_02_pd02.pdf A little more information about hookworms and the hookworm eradication project… Is this true about the males? That they detach after mating; I wonder how the life cycle would continue then.
Tuesday, December 30, 2008
Two patents on helminthic therapy: http://www.wipo.int/pctdb/en/wo.jsp?IA=WO2006%2F014907&WO=2006%2F014907&DISPLAY=\ STATUS http://www.freepatentsonline.com/EP1749534.html
Wednesday, December 10, 2008
Worm proteins injected intraperitoneally (shot in the abdomen) ameliorate colitis in mice. http://www3.interscience.wiley.com/journal/121530207/abstract?CRETRY=1&SRETRY=0 “Conclusions: Treatment with proteins of S. mansoni and A. caninum ameliorated TNBS-induced colitis in mice. S. mansoni proteins increased mRNA expression of regulatory cytokines while suppressing expression of proinflammatory cytokines. Therefore, we suggest a therapeutic potential for helminth proteins in the treatment [...]
One of the things those with Crohn’s disease ponder is the relationship between MAP (mycobacteria subspecies avian paratuberculosis) and helminths. MAP is one of the infections that some people think causes or contributes to Crohn’s, as it is abundant in our milk supply, survives pasturization and is very similar to Johne’s disease, which is basically [...]